In Vitro Mode of Action and Anti-thrombotic Activity of Boophilin, a Multifunctional Kunitz Protease Inhibitor from the Midgut of a Tick Vector of Babesiosis, Rhipicephalus microplus.

• Main Authors: Teresa C Assumpção (Author), Dongying Ma (Author), Daniella M Mizurini (Author), R Manjunatha Kini (Author), José M C Ribeiro (Author), Michail Kotsyfakis (Author), Robson Q Monteiro (Author), Ivo M B Francischetti (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Hematophagous mosquitos and ticks avoid host hemostatic system through expression of enzyme inhibitors targeting proteolytic reactions of the coagulation and complement cascades. While most inhibitors characterized to date were found in the salivary glands, relatively few others have been...