Structural analysis of recombinant human ubiquitin-conjugating enzyme UbcH5c

• المؤلفون الرئيسيون: Fangshu Wu (مؤلف), Junsheng Zhu (مؤلف), Honglin Li (مؤلف), Lili Zhu (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2017-05-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

UbcH5c belongs to the ubiquitin-conjugating enzyme family and plays an important role in catalyzing ubiquitination during TNF-α--triggered NF-κB activation. Therefore, UbcH5c is a potent therapeutic target for the treatment of inflammatory and autoimmune diseases induced by aberrant activation of NF...