Early neonatal loss of inhibitory synaptic input to the spinal motor neurons confers spina bifida-like leg dysfunction in a chicken model

• Main Authors: Md. Sakirul Islam Khan (Author), Hiroaki Nabeka (Author), Farzana Islam (Author), Tetsuya Shimokawa (Author), Shouichiro Saito (Author), Xuan Li (Author), Soichiro Kawabe (Author), Fumihiko Hamada (Author), Tetsuya Tachibana (Author), Seiji Matsuda (Author)
• Format: Book
• Published: The Company of Biologists, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Spina bifida aperta (SBA), one of the most common congenital malformations, causes lifelong neurological complications, particularly in terms of motor dysfunction. Fetuses with SBA exhibit voluntary leg movements in utero and during early neonatal life, but these disappear within the first few weeks...