Identification of potent aldose reductase inhibitors as antidiabetic (Anti-hyperglycemic) agents using QSAR based virtual Screening, molecular Docking, MD simulation and MMGBSA approaches

• Main Authors: Ravindra L. Bakal (Author), Rahul D. Jawarkar (Author), J.V. Manwar (Author), Minal S. Jaiswal (Author), Arabinda Ghosh (Author), Ajaykumar Gandhi (Author), Magdi E.A. Zaki (Author), Sami Al-Hussain (Author), Abdul Samad (Author), Vijay H. Masand (Author), Nobendu Mukerjee (Author), Syed Nasir Abbas Bukhari (Author), Praveen Sharma (Author), Israa Lewaa (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aldose reductase (AR) enzyme is an important target enzyme in the development of therapeutics against hyperglycaemia induced health complications such as retinopathy, etc. In the present study, a quantitative structure activity relationship (QSAR) evaluation of a dataset of 226 reported AR inhib...