Cathelicidins Induce Toll-Interacting Protein Synthesis to Prevent Apoptosis in Colonic Epithelium

• Main Authors: Ravi Holani (Author), Chathurika Rathnayaka (Author), Graham A.D. Blyth (Author), Anshu Babbar (Author), Priyoshi Lahiri (Author), Daniel Young (Author), Antoine Dufour (Author), Morley D. Hollenberg (Author), Derek M. McKay (Author), Eduardo R. Cobo (Author)
• Format: Book
• Published: Karger Publishers, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cathelicidin peptides secreted by leukocytes and epithelial cells are microbicidal but also regulate pathogen sensing via toll-like receptors (TLRs) in the colon by mechanisms that are not fully understood. Herein, analyses with the attaching/effacing pathogen Citrobacter rodentium model of colitis...