Involvement of a Multidrug Efflux Pump and Alterations in Cell Surface Structure in the Synergistic Antifungal Activity of Nagilactone E and Anethole against Budding Yeast <i>Saccharomyces cerevisiae</i>

• Main Authors: Yuki Ueda (Author), Yuhei O. Tahara (Author), Makoto Miyata (Author), Akira Ogita (Author), Yoshihiro Yamaguchi (Author), Toshio Tanaka (Author), Ken-ichi Fujita (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nagilactone E, an antifungal agent derived from the root bark of <i>Podocarpus nagi</i>, inhibits 1,3-β glucan synthesis; however, its inhibitory activity is weak. Anethole, the principal component of anise oil, enhances the antifungal activity of nagilactone E. We aimed to determine the...