Utility of physiologically based pharmacokinetic modeling to predict inter-antibody variability in monoclonal antibody pharmacokinetics in mice

• Váldodahkkit: Shufang Liu (Dahkki), Sara C. Humphreys (Dahkki), Kevin D. Cook (Dahkki), Kip P. Conner (Dahkki), Ana R. Correia (Dahkki), Alex W. Jacobitz (Dahkki), Melissa Yang (Dahkki), Ronya Primack (Dahkki), Marcus Soto (Dahkki), Rupa Padaki (Dahkki), Mariusz Lubomirski (Dahkki), Richard Smith (Dahkki), Marissa Mock (Dahkki), Veena A. Thomas (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

ABSTRACTIn this investigation, we tested the hypothesis that a physiologically based pharmacokinetic (PBPK) model incorporating measured in vitro metrics of off-target binding can largely explain the inter-antibody variability in monoclonal antibody (mAb) pharmacokinetics (PK). A diverse panel of 83...