Therapeutic Angiogenesis by a "Dynamic Duo": Simultaneous Expression of HGF and VEGF165 by Novel Bicistronic Plasmid Restores Blood Flow in Ischemic Skeletal Muscle

• Main Authors: Ekaterina Slobodkina (Author), Maria Boldyreva (Author), Maxim Karagyaur (Author), Roman Eremichev (Author), Natalia Alexandrushkina (Author), Vadim Balabanyan (Author), Zhanna Akopyan (Author), Yelena Parfyonova (Author), Vsevolod Tkachuk (Author), Pavel Makarevich (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Therapeutic angiogenesis is a promising strategy for relief of ischemic conditions, and gene delivery was used to stimulate blood vessels' formation and growth. We have previously shown that intramuscular injection of a mixture containing plasmids encoding vascular endothelial growth factor (VE...