Population Pharmacokinetic Study of Cefathiamidine in Infants With Augmented Renal Clearance

• Main Authors: Bin Du (Author), Yue Zhou (Author), Bo-Hao Tang (Author), Yue-E Wu (Author), Xin-Mei Yang (Author), Hai-Yan Shi (Author), Bu-Fan Yao (Author), Guo-Xiang Hao (Author), Dian-Ping You (Author), John van den Anker (Author), Yi Zheng (Author), Wei Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Augmented renal clearance (ARC) of primarily renally eliminated antibacterial agents may result in subtherapeutic antibiotic concentrations and, as a consequence, worse clinical outcomes. Cefathiamidine is frequently used as empirical antimicrobial therapy in children with ARC, but pharm...