Carbosilane Dendrimers Loaded with siRNA Targeting Nrf2 as a Tool to Overcome Cisplatin Chemoresistance in Bladder Cancer Cells

• Main Authors: Leanne Ambrosio (Author), Monica Argenziano (Author), Marie Angèle Cucci (Author), Margherita Grattarola (Author), Inge A.M. de Graaf (Author), Chiara Dianzani (Author), Giuseppina Barrera (Author), Javier Sánchez Nieves (Author), Rafael Gomez (Author), Roberta Cavalli (Author), Stefania Pizzimenti (Author)
• Format: Book
• Published: MDPI AG, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is considered as the master regulator of antioxidant and cytoprotective gene expressions. Moreover, it plays a pivotal role in cancer progression. Nrf2 mediates the adaptive response which contributes to the resistance to ch...