Engineering hydrophobicity and manufacturability for optimized biparatopic antibody-drug conjugates targeting c-MET

• Main Authors: Andreas Evers (Author), Simon Krah (Author), Deniz Demir (Author), Ramona Gaa (Author), Desislava Elter (Author), Christian Schroeter (Author), Stefan Zielonka (Author), Nicolas Rasche (Author), Julia Dotterweich (Author), Christine Knuehl (Author), Achim Doerner (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTOptimal combinations of paratopes assembled into a biparatopic antibody have the capacity to mediate high-grade target cross-linking on cell membranes, leading to degradation of the target, as well as antibody and payload delivery in the case of an antibody-drug conjugate (ADC). In the work...