Anakinra to Mitigate Hemophagocytic Lymphohistiocytosis-Like Toxicity Following Chimeric Antigen Receptor T-cell Therapy in Pediatric B-cell ALL

• Main Authors: Na Yoon Lee (Author), Suejung Jo (Author), Jae Won Yoo (Author), Seongkoo Kim (Author), Jae Wook Lee (Author), Nack-Gyun Chung (Author), Bin Cho (Author)
• Format: Book
• Published: The Korean Society of Pediatric Hematology-Oncology, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hemophagocytic lymphohistiocytosis-like toxicity following chimeric antigen receptor (CAR)-T cell therapy (carHLH) is a rare and fulminant complication. Currently, there are neither well-established diagnostic criteria nor optimal treatment option for carHLH. Given the similarities of hyperinflammat...