Action mechanism of hypoglycemic principle 9-(R)-HODE isolated from cortex lycii based on a metabolomics approach

• Main Authors: Yueqiu Liu (Author), Xinyi Hu (Author), Wen Zheng (Author), Lu Zhang (Author), Luolan Gui (Author), Ge Liang (Author), Yong Zhang (Author), Liqiang Hu (Author), Xin Li (Author), Yi Zhong (Author), Tao Su (Author), Xin Liu (Author), Jingqiu Cheng (Author), Meng Gong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The 9-(R)-HODE is an active compound isolated from cortex lycii that showed significant hypoglycemic effects in our previous in vitro study. In this study, 9-(R)-HODE's in vivo hypoglycemic activity and effect on alleviating diabetic complications, together with its molecular mechanism, was inv...