Immunization with HIV-1 envelope T20-encoding DNA vaccines elicits cross-clade neutralizing antibody responses

• Main Authors: S. Stenler (Author), K. E. Lundin (Author), L. Hansen (Author), S. Petkov (Author), N. Mozafari (Author), M. Isaguliants (Author), P. Blomberg (Author), C. I. E. Smith (Author), D. M. Goldenberg (Author), C.-H. Chang (Author), K. Ljungberg (Author), J. Hinkula (Author), B. Wahren (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Genetic immunization is expected to induce the expression of antigens in a native form. The encoded peptide epitopes are presented on endogenous MHC molecules, mimicking antigen presentation during a viral infection. We have explored the potential of enfuvirtide (T20), a short HIV peptid...