Colonic epithelial cathelicidin (LL‐37) expression intensity is associated with progression of colorectal cancer and presence of CD8+ T cell infiltrate

• Main Authors: Ross J Porter (Author), Graeme I Murray (Author), Abdo Alnabulsi (Author), Matthew P Humphries (Author), Jacqueline A James (Author), Manuel Salto‐Tellez (Author), Stephanie G Craig (Author), Ji M Wang (Author), Teizo Yoshimura (Author), Mairi H McLean (Author)
• Format: Book
• Published: Wiley, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Colorectal cancer (CRC) remains a leading cause of cancer mortality. Here, we define the colonic epithelial expression of cathelicidin (LL‐37) in CRC. Cathelicidin exerts pleotropic effects including anti‐microbial and immunoregulatory functions. Genetic knockout of cathelicidin led to incr...