Application of UPLCâMS/MS for separation and quantification of 3α-Hydroxy Tibolone and comparative bioavailability of two Tibolone formulations in healthy volunteers

• Main Authors: Vijay P. Shinde (Author), Ashutosh Pudage (Author), Arvind Jangid (Author), Hiren Mistri (Author), P.K. Patel (Author)
• Format: Book
• Published: Elsevier, 2013-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A novel, fast, sensitive and robust method based on ultra-performance liquid chromatography coupled to atmospheric pressure electrospray ionization tandem mass spectrometry (UPLCâESI-MS/MS) has been developed to separate two Tibolone stereoisomers i.e., 3α-Hydroxy Tibolone and 3β-Hydroxy Tibolone...