Application of UPLCâMS/MS for separation and quantification of 3α-Hydroxy Tibolone and comparative bioavailability of two Tibolone formulations in healthy volunteers

• Egile Nagusiak: Vijay P. Shinde (Egilea), Ashutosh Pudage (Egilea), Arvind Jangid (Egilea), Hiren Mistri (Egilea), P.K. Patel (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2013-08-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

A novel, fast, sensitive and robust method based on ultra-performance liquid chromatography coupled to atmospheric pressure electrospray ionization tandem mass spectrometry (UPLCâESI-MS/MS) has been developed to separate two Tibolone stereoisomers i.e., 3α-Hydroxy Tibolone and 3β-Hydroxy Tibolone...