A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase

• Main Authors: Kamil Kuca (Author), Kamil Musilek (Author), Daniel Jun (Author), Jana Zdarova-Karasova (Author), Eugenie Nepovimova (Author), Ondrej Soukup (Author), Martina Hrabinova (Author), John Mikler (Author), Tanos C. C. Franca (Author), Elaine F. F. Da Cunha (Author), Alexandre A. De Castro (Author), Martin Valis (Author), Teodorico C. Ramalho (Author)
• Format: Book
• Published: BMC, 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Based on in vitro and in vivo rat experiments, the newly developed acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the treatment of tabun poisonings than currently fielded oximes. Methods To determine if this reactivating efficacy would extend...