Antiproliferative chromone derivatives induce K562 cell death through endogenous and exogenous pathways

• Main Authors: Runwei Jiao (Author), Fanxing Xu (Author), Xiaofang Huang (Author), Haonan Li (Author), Weiwei Liu (Author), Hao Cao (Author), Linghe Zang (Author), Zhanlin Li (Author), Huiming Hua (Author), Dahong Li (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of furoxan derivatives of chromone were prepared. The antiproliferative activities were tested against five cancer cell lines HepG2, MCF-7, HCT-116, B16, and K562, and two normal human cell lines L-02 and PBMCs. Among them, compound 15a exhibited the most potent antiproliferative activity....