Direct and indirect effects of age on dengue severity: The mediating role of secondary infection.

• Main Authors: Esther Annan (Author), Jesús Treviño (Author), Bingxin Zhao (Author), Alfonso J Rodriguez-Morales (Author), Ubydul Haque (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Severe dengue occurrence has been attributed to increasing age and different dengue virus (DENV) serotypes that cause secondary infections and immune-enhancing phenomena. Therefore, we examined if the effect of age on dengue severity was mediated by infectivity status while controlling for sex and r...