Delayed alveolar bone repair and osteonecrosis associated with Zoledronic Acid therapy in rats: macroscopic, microscopic and molecular analysis

• Main Authors: Gustavo Zanna FERREIRA (Author), Edson Virgílio ZEN FILHO (Author), Izabel Regina Fisher RUBIRA-BULLEN (Author), Gustavo Pompermaier GARLET (Author), Carlos Ferreira SANTOS (Author), Paulo Sérgio da Silva SANTOS (Author)
• Format: Book
• Published: University of São Paulo, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Objective This study aims to evaluate bone repair and the development of the medication related osteonecrosis of the jaw (MRONJ) associated with the use of zoledronic acid in Wistar rats. Methodology 48 male Wistar rats were divided into four groups: ZA, treated with intraperitoneal zoledro...