Evaluation of N-alkyl isatins and indoles as acetylcholinesterase and butyrylcholinesterase inhibitors

• Үндсэн зохиолчид: Kaitlyn N. Alcorn (Зохиогч), Isabelle A. Oberhauser (Зохиогч), Matthew D. Politeski (Зохиогч), Todd J. Eckroat (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

AbstractTwo series of N-alkyl isatins and N-alkyl indoles varying in size of the alkyl group were synthesised and evaluated for inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Among the N-alkyl isatins 4a-j, the addition of the N-alkyl group improved inhibition potency to...