Age-Related Decrease in Male Extra-Striatal Adenosine A1 Receptors Measured Using11C-MPDX PET

• Main Authors: Masahiro Mishina (Author), Yuichi Kimura (Author), Muneyuki Sakata (Author), Kenji Ishii (Author), Keiichi Oda (Author), Jun Toyohara (Author), Kazumi Kimura (Author), Kiichi Ishiwata (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adenosine A1 receptors (A1Rs) are widely distributed throughout the entire human brain, while adenosine A2A receptors (A2ARs) are present in dopamine-rich areas of the brain, such as the basal ganglia. A past study using autoradiography reported a reduced binding ability of A1R in the striatum of ol...