Identification of Glycyrrhiza as the rikkunshito constituent with the highest antagonistic potential on heterologously expressed 5HT3A receptors due to the action of flavonoids

• Main Authors: Robin eHerbrechter (Author), Paul M Ziemba (Author), Katrin M Hoffmann (Author), Hanns eHatt (Author), Markus eWerner (Author), Guenter eGisselmann (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The traditional Japanese phytomedicine rikkunshito is traditionally used for the treatment of gastrointestinal motility disorders, cachexia and nausea. These effects indicate 5-HT3 receptor antagonism, due to the involvement of these receptors in such pathophysiological processes. E.g. setrons, spec...