Is hematoxylin-eosin staining in rectal mucosal and submucosal biopsies still useful for the diagnosis of Hirschsprung disease?

• Main Authors: Suellen Serafini (Author), Maria Mercês Santos (Author), Ana Cristina Aoun Tannuri (Author), Maria Claudia Nogueira Zerbini (Author), Maria Cecília de Mendonça Coelho (Author), Josiane de Oliveira Gonçalves (Author), Uenis Tannuri (Author)
• Format: Book
• Published: BMC, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Hematoxylin-eosin (HE) staining of a full-thickness rectal wall fragment is classically used for the diagnosis of Hirschsprung disease (HD). However, this technique requires large fragments for a better diagnosis. Additionally, the histochemical and immunohistochemical methods of...