NDRG1 acts as an oncogene in triple-negative breast cancer and its loss sensitizes cells to mitochondrial iron chelation

• Main Authors: Sukanya B. Jadhav (Author), Michaela Vondrackova (Author), Petra Potomova (Author), Cristian Sandoval-Acuña (Author), Jana Smigova (Author), Kristyna Klanicova (Author), Daniel Rosel (Author), Jan Brabek (Author), Jan Stursa (Author), Lukas Werner (Author), Jaroslav Truksa (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multiple studies indicate that iron chelators enhance their anti-cancer properties by inducing NDRG1, a known tumor and metastasis suppressor. However, the exact role of NDRG1 remains controversial, as newer studies have shown that NDRG1 can also act as an oncogene. Our group recently introduced mit...