PIK3CA-Related Overgrowth Spectrum From Diagnosis to Targeted Therapy: A Case of CLOVES Syndrome Treated With Alpelisib

• Main Authors: Angelica Pagliazzi (Author), Teresa Oranges (Author), Giovanna Traficante (Author), Chiara Trapani (Author), Flavio Facchini (Author), Alessandra Martin (Author), Alessandro Semeraro (Author), Anna Perrone (Author), Cesare Filippeschi (Author), Sabrina Giglio (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PIK3CA-related overgrowth spectrum (PROS) is an umbrella term referring to various clinical entities, which share the same pathogenetic mechanism. These conditions are caused by somatic gain-of-function mutations in PIK3CA, which encodes the 110-kD catalytic α subunit of PI3K (p110α). These PIK3CA m...