PIK3CA-Related Overgrowth Spectrum From Diagnosis to Targeted Therapy: A Case of CLOVES Syndrome Treated With Alpelisib

PIK3CA-related overgrowth spectrum (PROS) is an umbrella term referring to various clinical entities, which share the same pathogenetic mechanism. These conditions are caused by somatic gain-of-function mutations in PIK3CA, which encodes the 110-kD catalytic α subunit of PI3K (p110α). These PIK3CA m...

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Main Authors: Angelica Pagliazzi (Author), Teresa Oranges (Author), Giovanna Traficante (Author), Chiara Trapani (Author), Flavio Facchini (Author), Alessandra Martin (Author), Alessandro Semeraro (Author), Anna Perrone (Author), Cesare Filippeschi (Author), Sabrina Giglio (Author)
Format: Book
Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
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