PIK3CA-Related Overgrowth Spectrum From Diagnosis to Targeted Therapy: A Case of CLOVES Syndrome Treated With Alpelisib

• Autors principals: Angelica Pagliazzi (Autor), Teresa Oranges (Autor), Giovanna Traficante (Autor), Chiara Trapani (Autor), Flavio Facchini (Autor), Alessandra Martin (Autor), Alessandro Semeraro (Autor), Anna Perrone (Autor), Cesare Filippeschi (Autor), Sabrina Giglio (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

PIK3CA-related overgrowth spectrum (PROS) is an umbrella term referring to various clinical entities, which share the same pathogenetic mechanism. These conditions are caused by somatic gain-of-function mutations in PIK3CA, which encodes the 110-kD catalytic α subunit of PI3K (p110α). These PIK3CA m...