Cytotoxicity Evaluation of Chloroquine and Hydroxychloroquine in Multiple Cell Lines and Tissues by Dynamic Imaging System and Physiologically Based Pharmacokinetic Model

• Main Authors: Jianling Yang (Author), Zhengyang Guo (Author), Xu Liu (Author), Qi Liu (Author), Meng Wu (Author), Xueting Yao (Author), Yang Liu (Author), Cheng Cui (Author), Haiyan Li (Author), Chunli Song (Author), Dongyang Liu (Author), Lixiang Xue (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chloroquine (CQ) and hydroxychloroquine (HCQ) have been challenged in treating COVID-19 patients and still under debate due to the uncertainty regarding the effectiveness and safety, and there is still lack of the systematic study on the toxicity of these two drugs. To further uncover the toxicity p...