Dysfunction of Akt/FoxO3a/Atg7 regulatory loop magnifies obesity-regulated muscular mass decline

• Main Authors: Yang Yu (Author), Jing Yang (Author), Lixia Zheng (Author), Han Su (Author), Sunrun Cao (Author), Xuehan Jiang (Author), Xiyan Liu (Author), Weiwei Liu (Author), Zhuo Wang (Author), Fang Meng (Author), Hongde Xu (Author), Deliang Wen (Author), Chen Sun (Author), Xiaoyu Song (Author), Antonio Vidal-Puig (Author), Liu Cao (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Myoprotein degradation accelerates in obese individuals, resulting in a decline in muscular mass. Atg7 plays a crucial role in regulating protein stability and function through both autophagy-dependent and independent pathways. As obesity progresses, the expression of Atg7 gradually rise...