Hypothalamic POMC deficiency increases circulating adiponectin despite obesity

• Main Authors: Hui Yu (Author), Kavaljit H. Chhabra (Author), Zoe Thompson (Author), Graham L. Jones (Author), Sylee Kiran (Author), Gary Shangguan (Author), Malcolm J. Low (Author)
• Format: Book
• Published: Elsevier, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The steep rise in the prevalence of obesity and its related metabolic syndrome have become a major worldwide health concerns. Melanocortin peptides from hypothalamic arcuate nucleus (Arc) POMC neurons induce satiety to limit food intake. Consequently, Arc Pomc-deficient mice (ArcPomc−/−)...