PKD3 promotes metastasis and growth of oral squamous cell carcinoma through positive feedback regulation with PD-L1 and activation of ERK-STAT1/3-EMT signalling

• Main Authors: Bomiao Cui (Author), Jiao Chen (Author), Min Luo (Author), Yiying Liu (Author), Hongli Chen (Author), Die Lü (Author), Liwei Wang (Author), Yingzhu Kang (Author), Yun Feng (Author), Libin Huang (Author), Ping Zhang (Author)
• Format: Bog
• Udgivet: Nature Publishing Group, 2021-03-01T00:00:00Z.
• Fag: article
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Abstract Oral squamous cell carcinoma (OSCC) has a high incidence of metastasis. Tumour immunotherapy targeting PD-L1 or PD-1 has been revolutionary; however, only a few patients with OSCC respond to this treatment. Therefore, it is essential to gain insights into the molecular mechanisms underlying...