An MMP-9 exclusive neutralizing antibody attenuates blood-brain barrier breakdown in mice with stroke and reduces stroke patient-derived MMP-9 activity

• Main Authors: Yabin Ji (Author), Qiang Gao (Author), Yinzhong Ma (Author), Fang Wang (Author), Xixi Tan (Author), Dengpan Song (Author), Ruby L.C. Hoo (Author), Zening Wang (Author), Xin Ge (Author), Hongjie Han (Author), Fuyou Guo (Author), Junlei Chang (Author)
• Format: Book
• Published: Elsevier, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rapid upregulation of matrix metalloproteinase 9 (MMP-9) leads to blood-brain barrier (BBB) breakdown following stroke, but no MMP-9 inhibitors have been approved in clinic largely due to their low specificities and side effects. Here, we explored the therapeutic potential of a human IgG monoclonal...