Potential mechanisms underlying podophyllotoxin-induced cardiotoxicity in male rats: toxicological evidence chain (TEC) concept

• Main Authors: Kaiyue Ma (Author), Lu Sun (Author), Chunxue Jia (Author), Hongqian Kui (Author), Jiaqi Xie (Author), Shidan Zang (Author), Shixin Huang (Author), Jinfeng Que (Author), Chuanxin Liu (Author), Jianmei Huang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionPodophyllotoxin (PPT) is a high-content and high-activity compound extracted from the traditional Chinese medicinal plant Dysosma versipellis (DV) which exhibits various biological activities. However, its severe toxicity limits its use. In clinical settings, patients with DV poisoning o...