Possible A2E Mutagenic Effects on RPE Mitochondrial DNA from Innovative RNA-Seq Bioinformatics Pipeline

• Main Authors: Luigi Donato (Author), Concetta Scimone (Author), Simona Alibrandi (Author), Alessandro Pitruzzella (Author), Federica Scalia (Author), Rosalia D'Angelo (Author), Antonina Sidoti (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondria are subject to continuous oxidative stress stimuli that, over time, can impair their genome and lead to several pathologies, like retinal degenerations. Our main purpose was the identification of mtDNA variants that might be induced by intense oxidative stress determined by <i>N&l...