Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging

• Main Authors: Marisol Fernández-Ortiz (Author), Ramy K. A. Sayed (Author), José Fernández-Martínez (Author), Antonia Cionfrini (Author), Paula Aranda-Martínez (Author), Germaine Escames (Author), Tomás de Haro (Author), Darío Acuña-Castroviejo (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aging is a major risk for cardiovascular diseases (CVD). Age-related disorders include oxidative stress, mitochondria dysfunction, and exacerbation of the NF-κB/NLRP3 innate immune response pathways. Some of the molecular mechanisms underlying these processes, however, remain unclear. This study tes...