High Phosphate Induces and Klotho Attenuates Kidney Epithelial Senescence and Fibrosis

• المؤلفون الرئيسيون: Jenny Maique (مؤلف), Brianna Flores (مؤلف), Mingjun Shi (مؤلف), Sierra Shepard (مؤلف), Zhiyong Zhou (مؤلف), Shirely Yan (مؤلف), Orson W. Moe (مؤلف), Ming Chang Hu (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2020-08-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Cellular senescence is an irreversible cell growth arrest and is associated with aging and age-related diseases. High plasma phosphate (Pi) and deficiency of Klotho contribute to aging and kidney fibrosis, a pathological feature in the aging kidney and chronic kidney disease. This study examined the...