High Phosphate Induces and Klotho Attenuates Kidney Epithelial Senescence and Fibrosis

• Main Authors: Jenny Maique (Author), Brianna Flores (Author), Mingjun Shi (Author), Sierra Shepard (Author), Zhiyong Zhou (Author), Shirely Yan (Author), Orson W. Moe (Author), Ming Chang Hu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cellular senescence is an irreversible cell growth arrest and is associated with aging and age-related diseases. High plasma phosphate (Pi) and deficiency of Klotho contribute to aging and kidney fibrosis, a pathological feature in the aging kidney and chronic kidney disease. This study examined the...