Neutrophil elastase downmodulates native G-CSFR expression and granulocyte-macrophage colony formation

• Main Authors: Kindwall-Keller Tamila L (Author), Druhan Lawrence J (Author), Loveland Megan (Author), Massullo Pam R (Author), Piper Melissa G (Author), Ai Jing (Author), Copelan Alexander (Author), Avalos Belinda R (Author)
• Format: Book
• Published: BMC, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The granulocyte colony-stimulating factor receptor (G-CSFR) plays a critical role in maintaining homeostatic levels of circulating neutrophils (PMN). The mechanisms modulating G-CSFR surface expression to prevent chronic neutrophilia...