Benzothiazepines, diltiazem and JTV-519, exert an anxiolytic-like effect via neurosteroid biosynthesis in mice

• Main Authors: Kazumi Yoshizawa (Author), Kozue Nakashima (Author), Mizuho Tabuchi (Author), Ayano Okumura (Author), Yuko Nakatake (Author), Mitsuhiko Yamada (Author), Yayoi Tsuneoka (Author), Tatsuya Higashi (Author)
• Format: Book
• Published: Elsevier, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated whether benzothiazepines could produce anxiolytic effects via allopregnanolone (ALLO) biosynthesis in mice. We compared the behavioral effects caused by benzothiazepines to those caused by carbamazepine and sodium valproate. We found that a pretreatment with finasteride (a 5 alpha-re...