Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease

• Main Authors: Muneer G. Hasham (Author), Nicoleta Baxan (Author), Daniel J. Stuckey (Author), Jane Branca (Author), Bryant Perkins (Author), Oliver Dent (Author), Ted Duffy (Author), Tolani S. Hameed (Author), Sarah E. Stella (Author), Mohammed Bellahcene (Author), Michael D. Schneider (Author), Sian E. Harding (Author), Nadia Rosenthal (Author), Susanne Sattler (Author)
• Format: Book
• Published: The Company of Biologists, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Systemic autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) show significant heart involvement and cardiovascular morbidity, which can be due to systemically increased levels of inflammation or direct autoreactivity targeting cardiac tissue. Despite high cli...