Identification and quantitation of hinge cysteinylation on endogenous IgG2 antibodies from human serum

• Main Authors: Luladey Ayalew (Author), Alicia D. D'Souza (Author), Yan Chen (Author), Michael T. Kim (Author)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Cysteinylation is a post-translational modification (PTM) that occurs when a cysteine residue on a protein forms a disulfide bond with a terminal cysteine molecule. This PTM has been found in the hinge region of several recombinant therapeutic IgG2 antibodies, but the impact of cysteinylation on the...