Identification and quantitation of hinge cysteinylation on endogenous IgG2 antibodies from human serum

Cysteinylation is a post-translational modification (PTM) that occurs when a cysteine residue on a protein forms a disulfide bond with a terminal cysteine molecule. This PTM has been found in the hinge region of several recombinant therapeutic IgG2 antibodies, but the impact of cysteinylation on the...

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Hoofdauteurs: Luladey Ayalew (Auteur), Alicia D. D'Souza (Auteur), Yan Chen (Auteur), Michael T. Kim (Auteur)
Formaat: Boek
Gepubliceerd in: Taylor & Francis Group, 2020-01-01T00:00:00Z.
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