Glucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA

• Main Authors: Jonathan L.S. Esguerra (Author), Jones K. Ofori (Author), Mototsugu Nagao (Author), Yuki Shuto (Author), Alexandros Karagiannopoulos (Author), Joao Fadista (Author), Hitoshi Sugihara (Author), Leif Groop (Author), Lena Eliasson (Author)
• Format: Book
• Published: Elsevier, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: A widely recognized metabolic side effect of glucocorticoid (GC) therapy is steroid-induced diabetes mellitus (DM). However, studies on the molecular basis of GC-induced pancreatic beta cell dysfunction in human beta cells are lacking. The significance of non-coding RNAs in various cellul...