Glucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA

• Autori principali: Jonathan L.S. Esguerra (Autore), Jones K. Ofori (Autore), Mototsugu Nagao (Autore), Yuki Shuto (Autore), Alexandros Karagiannopoulos (Autore), Joao Fadista (Autore), Hitoshi Sugihara (Autore), Leif Groop (Autore), Lena Eliasson (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2020-02-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Objective: A widely recognized metabolic side effect of glucocorticoid (GC) therapy is steroid-induced diabetes mellitus (DM). However, studies on the molecular basis of GC-induced pancreatic beta cell dysfunction in human beta cells are lacking. The significance of non-coding RNAs in various cellul...