An Alignment-Independent 3D-QSAR Study of FGFR2 Tyrosine Kinase Inhibitors

• Main Authors: Behzad Jafari (Author), Maryam Hamzeh-Mivehroud (Author), Ali Akbar Alizadeh (Author), Mehdi Sharifi (Author), Siavoush Dastmalchi (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Receptor tyrosine kinase (RTK) inhibitors are widely used pharmaceuticals in cancer therapy. Fibroblast growth factor receptors (FGFRs) are members of RTK superfamily which are highly expressed on the surface of carcinoma associate fibroblasts (CAFs). The involvement of FGFRs in different t...