Ultrasound and Transcriptomics Identify a Differential Impact of Cisplatin and Histone Deacetylation on Tumor Structure and Microenvironment in a Patient-Derived In Vivo Model of Gastric Cancer

• Main Authors: Aina Venkatasamy (Author), Eric Guerin (Author), Anais Blanchet (Author), Christophe Orvain (Author), Véronique Devignot (Author), Matthieu Jung (Author), Alain C. Jung (Author), Marie-Pierre Chenard (Author), Benoit Romain (Author), Christian Gaiddon (Author), Georg Mellitzer (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The reasons behind the poor efficacy of transition metal-based chemotherapies (e.g., cisplatin) or targeted therapies (e.g., histone deacetylase inhibitors, HDACi) on gastric cancer (GC) remain elusive and recent studies suggested that the tumor microenvironment could contribute to the resistance. H...