Correlated analytical and functional evaluation of higher order structure perturbations from oxidation of NISTmAb

• Main Authors: Tsega L. Solomon (Author), Frank Delaglio (Author), John P. Giddens (Author), John P. Marino (Author), Yihua Bruce Yu (Author), Marc B. Taraban (Author), Robert G. Brinson (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTThe clinical efficacy and safety of protein-based drugs such as monoclonal antibodies (mAbs) rely on the integrity of the protein higher order structure (HOS) during product development, manufacturing, storage, and patient administration. As mAb-based drugs are becoming more prevalent in the...