Correlated analytical and functional evaluation of higher order structure perturbations from oxidation of NISTmAb

• Egile Nagusiak: Tsega L. Solomon (Egilea), Frank Delaglio (Egilea), John P. Giddens (Egilea), John P. Marino (Egilea), Yihua Bruce Yu (Egilea), Marc B. Taraban (Egilea), Robert G. Brinson (Egilea)
• Formatua: Liburua
• Argitaratua: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

ABSTRACTThe clinical efficacy and safety of protein-based drugs such as monoclonal antibodies (mAbs) rely on the integrity of the protein higher order structure (HOS) during product development, manufacturing, storage, and patient administration. As mAb-based drugs are becoming more prevalent in the...