Microtiter plate-based chemistry and in situ screening: SuFEx-enabled lead discovery of selective AChE inhibitors

• Main Authors: Kun Tang (Author), Huan-Huan Li (Author), Chengyao Wu (Author), Shi-Long Zhang (Author), Jian-Guo Yang (Author), Wenjian Tang (Author), Hua-Li Qin (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sulphur fluoride exchange (SuFEx) is a category of click chemistry that enables covalent linking of modular units through sulphur connective hubs. Here, we reported an efficient synthesis and in situ screening method for building a library of sulphonamides on the picomolar scale by SuFEx reaction be...