Influence of MIF polymorphisms on CpG island hyper-methylation of CDKN2A in the patients with ulcerative colitis

• Main Authors: Naoko Sakurai (Author), Tomoyuki Shibata (Author), Masakatsu Nakamura (Author), Hikaru Takano (Author), Tasuku Hayashi (Author), Masafumi Ota (Author), Tomoe Nomura-Horita (Author), Ranji Hayashi (Author), Takeo Shimasaki (Author), Toshimi Ostuka (Author), Tomomitsu Tahara (Author), Tomiyasu Arisawa (Author)
• Format: Book
• Published: BMC, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background CDKN2A hypermethylation is among the major events associated with carcinogenesis and is also observed in non-neoplastic colonic mucosa in patients with ulcerative colitis (UC). Macrophage migration inhibitory factor (MIF) plays a crucial role in promoting gastrointestinal inflamm...