Deletion of intestinal SIRT1 exacerbated muscle wasting in cirrhotic mice by decreasing the intestinal concentration of short-chain fatty acids and inflammation

• Main Authors: Chien-Fu Hsu (Author), Chia-Chang Huang (Author), Tze-Tze Liu (Author), Ueng-Cheng Yang (Author), Chih-Wei Liu (Author), Shiang-Fen Huang (Author), Ying-Ying Yang (Author), Yi-Hsiang Huang (Author), Ming-Chih Hou (Author), Han-Chieh Lin (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Systemic sirtuin 1 (SIRT1) activation alleviates muscle wasting and improves muscle function by downregulation of myotropic and proteolytic markers. In this study, we evaluated the effects of the intestinal Sirt1 deletion on the dysregulated gutmuscle axis in cirrhotic mice. Cirrhosis-related muscle...