Deletion of intestinal SIRT1 exacerbated muscle wasting in cirrhotic mice by decreasing the intestinal concentration of short-chain fatty acids and inflammation

• Үндсэн зохиолчид: Chien-Fu Hsu (Зохиогч), Chia-Chang Huang (Зохиогч), Tze-Tze Liu (Зохиогч), Ueng-Cheng Yang (Зохиогч), Chih-Wei Liu (Зохиогч), Shiang-Fen Huang (Зохиогч), Ying-Ying Yang (Зохиогч), Yi-Hsiang Huang (Зохиогч), Ming-Chih Hou (Зохиогч), Han-Chieh Lin (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2021-12-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Systemic sirtuin 1 (SIRT1) activation alleviates muscle wasting and improves muscle function by downregulation of myotropic and proteolytic markers. In this study, we evaluated the effects of the intestinal Sirt1 deletion on the dysregulated gutmuscle axis in cirrhotic mice. Cirrhosis-related muscle...