CRM1 Is a Direct Cellular Target of the Natural Anti-cancer Agent Plumbagin

• Main Authors: Xuejiao Liu (Author), Mingshan Niu (Author), Xiaoyu Xu (Author), Wei Cai (Author), Lingyu Zeng (Author), Xiuping Zhou (Author), Rutong Yu (Author), Kailin Xu (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Plumbagin, a naphthoquinone derived from the medicinal plant Plumbago zeylanica, has been shown to exert anti-cancer and anti-proliferative activities in vitro as well as in animal tumor models. However, the mechanism underlying its anti-tumor action still remains unclear. CRM1 is a nuclear export r...