Distinct Phenotypes Caused by Mutation of MSH2 in Trypanosome Insect and Mammalian Life Cycle Forms Are Associated with Parasite Adaptation to Oxidative Stress.

• Main Authors: Viviane Grazielle-Silva (Author), Tehseen Fatima Zeb (Author), Jason Bolderson (Author), Priscila C Campos (Author), Julia B Miranda (Author), Ceres L Alves (Author), Carlos R Machado (Author), Richard McCulloch (Author), Santuza M R Teixeira (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:DNA repair mechanisms are crucial for maintenance of the genome in all organisms, including parasites where successful infection is dependent both on genomic stability and sequence variation. MSH2 is an early acting, central component of the Mismatch Repair (MMR) pathway, which is respons...