In vivo and in vitro protective effects of shengmai injection against doxorubicin-induced cardiotoxicity

• Main Authors: Peng Zhou (Author), Ge Gao (Author), Chun-chun Zhao (Author), Jing-ya Li (Author), Jian-fei Peng (Author), Shu-shu Wang (Author), Rui Song (Author), Hui Shi (Author), Liang Wang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context Shengmai injection (SMI) has been used to treat heart failure.Objective This study determines the molecular mechanisms of SMI against cardiotoxicity caused by doxorubicin (DOX).Materials and methods In vivo, DOX (15 mg/kg) was intraperitoneally injected in model, Dex (dexrazoxane), SMI-L (2....